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Bioactive Cycloartane-Type Triterpene Glycosides from Astragalus elongatus
(Çalış, İhsan,) |
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Bibliographical information (record 265969) |
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- Together with two known cycloartane-type glycosides, askendosides D(3-O-[alpha-arabino-pyranosyl-(1 -> 2)-beta-xylopyranosyl]-6-O-beta-xylopyranosyl-cycloastragenol, 2) and G (3-O-[alpha-arabinopyranosyl-(1 -> 2)-beta-xylopyranosyl]-16-0-beta-glucopyranosyl-3 beta,6 alpha,16 beta,24(R),25-pentahydroxycycloartane, 3), also a new monodesmosidic cycloartane-type glycoside, elongatoside (1), was isolated from the roots of Astragalits elongatus and identified as 3-O-[alpha-arabinopyranosyl-(1 -> 2)-beta-xylopyranosy]-cycloastragenol. All structures were unambiguously determined by means of spectroscopic and spectrometric methods (1D and 2D NMR, ESI-MS). The isolated compounds were tested for the inhibition of proliferation and ICAM-1 expression in vitro using the human microvascular endothelial cell line (HMEC-1). 1 showed weak activity in the ICAM-1 assay.
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Library |
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EOL-1255
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Item available
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NEU Grand LibraryOnline (QU4.3 .B56 2008)
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Online electronic |
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