NEU GRAND LIBRARY
Opening Hours: Mon/Sat 24 hours Sun 08.00-16.00 | E-mail: library@neu.edu.tr
 

You are not logged in Show Basket
  Home     Advanced Search     Back  
  Brief display     MARC Display     Reserve  
Activation of the central histaminergic system mediates arachidonic-acid-induced cardiovascular effects (Altinbas, Burcin.)
Bibliographical information (record 264089)
Help
Activation of the central histaminergic system mediates arachidonic-acid-induced cardiovascular effects
Author:
Altinbas, Burcin. Search Author in Amazon Books

Publisher:
Canadıan Scıence Publıshıng,
Edition:
2014.
Classification:
QP356.3
URL:

http://library.neu.edu.tr:2048/login?url=http://dx.doi.org/10.1139/cjpp-2014-0043
Detailed notes
    - The aim of this study was to explain the involvement of the central histaminergic system in arachidonic acid (AA)-induced cardiovascular effects in normotensive rats using hemodynamic, immunohistochemistry, and microdialysis studies. Intracerebroventricularly (i.c.v.) administered AA (0.25, 0.5, and 1.0 mu mol) induced dose-and time-dependent increases in mean arterial pressure and decreased heart rate in conscious normotensive Sprague-Dawley rats. Central injection of AA (0.5 mu mol) also increased posterior hypothalamic extracellular histamine levels and produced strong COX-1 but not COX-2 immunoreactivity in the posterior hypothalamus of rats. Moreover, the cardiovascular effects and COX-1 immunoreactivity in the posterior hypothalamus induced by AA (0.5 mu mol; i.c.v.) were almost completely blocked by the H2 receptor antagonist ranitidine (50 and 100 nmol; i.c.v.) and partially blocked by the H1 receptor blocker chlorpheniramine (100 nmol; i.c.v.) and the H3-H4 receptor antagonist thioperamide (50 and 100 nmol; i.c.v.). In conclusion, these results indicate that centrally administered AA induces pressor and bradycardic responses in conscious rats. Moreover, we suggest that AA may activate histaminergic neurons and increase extracellular histamine levels, particularly in the posterior hypothalamus. Acting as a neurotransmitter, histamine is potentially involved in AA-induced cardiovascular effects under normotensive conditions.
Related links
Items (1)
Barcode
Status
Library
Section
EOL-435
Item available
NEU Grand LibraryOnline (QP356.3 .A28 2014)
Online electronic

NEAR EAST UNIVERSITY GRAND LIBRARY +90 (392) 223 64 64 Ext:5536. Near East Boulevard, Nicosia, TRNC
This software is developed by NEU Library and it is based on Koha OSS
conforms to MARC21 library data transfer rules.