a Record control number 000284300600009

a ISSN 1521-6616

a Original cataloging agency NEU GrandLibrary

a Language code of text/sound track or separate title eng

a Classification number QW504

b Item number .O98 2010

a Personal name Ozen, Ahmet.

h Medium Electronic Document

a Title Outcome of hypogammaglobulinemia in children: Immunoglobulin levels as predictors.

c Statement of responsibility, etc Ahmet Ozen, Safa Baris, Elif Karakoc-Aydiner, Cevdet Ozdemir.

b Name of publisher, distributor, etc Academic Press Inc Elsevier Science,

c Date of publication, distribution, etc 2010.

a Place of publication, distribution, etc San Diego :

a Summary, etc We evaluated 131 children (M=88, F=43) with hypogammaglobulinemia Data was analyzed mainly for delineating predictor factors for outcome The distance from the lower limit of normal (-2SD) for any single measurement of immunoglobulins (Ig) was calculated and transformed into Ig scores Mean age and duration of follow up were 5 06 +/- 4 05 and 3 7 +/- 3 03 years, respectively The diagnoses were 22 CVID, 16 IgA deficiency, 33 transient hypogammaglobulinemia of childhood (THC), 3 selective IgM deficiency and 57 unclassified hypogammaglobulinemia (UCH) Low IgA scores (<-0 124) at presentation were indicative of subsequent development of IgA deficiency or CVID, whereas low IgM score (<-0 038) pointed towards more severe and persistent phenotypes Combination of low IgM score between 2 and 5 years, impaired antibody response and low B cell counts enabled us to predict persistence of hypogammaglobulinemia beyond 5 years (specificity = 90 5% and PPV = 94 9%) and chronic lung disease (sensitivity =90 4% and specificity = 68 3%) The set of criteria including low IgM scores, impaired antibody response and low B cell counts provided a high predictive value in detecting those with persistent hypogammaglobulinemia (C) 2010 Elsevier Inc All rights reserved.

a Topical term or geographic name as entry element Near East University Article

a Topical term or geographic name as entry element Yakın Doğu Üniversitesi Makale

a Topical term or geographic name as entry element Immunology

a Topical term or geographic name as entry element Unclassified Hypogammaglobulinemia

a Topical term or geographic name as entry element Predictors

g Relationship information DEC 2010,Vol 137Issue 3, p374-383

t Title Clinical Immunology

x International Standard Serial Number 15216616

u Uniform Resource Identifier http://library.neu.edu.tr:2048/login?url=http://dx.doi.org/10.1016/j.clim.2010.08.010