a Record control number 000327575300014

a ISSN 1019-5149

a Original cataloging agency NEU GrandLibrary

a Language code of text/sound track or separate title eng

a Classification number WL18.2

b Item number .N48 2013

a Personal name Hasturk, Askin Esen.

h Medium Electronic Document

a Title Neuroprotective Effect of Magnesium Sulfate and Dexamethasone on Intrauterine Ischemia in the Fetal Rat Brain: Ultrastructural Evaluation

c Statement of responsibility, etc Askin Esen Hastürk, Ferhat Harman, Türkan Arca, Mustafa SargoN, Kamer Kılınç, Erkan Kaptanoğlu.

b Name of publisher, distributor, etc Turkısh Neurosurgıcal Soc,

c Date of publication, distribution, etc 2013.

a Summary, etc AIM: The aim of this study was to investigate the neuroprotective effect of magnesium sulfate and dexamethasone on oxidative damage in intrauterine ischemia. MATERIAL and METHODS: In this study, 19-day pregnant rats were divided into five groups. Fetal brain ischemia was achieved in the ischemia/reperfusion (I/R) group by bilaterally closing the utero-ovarian artery with aneurysm clips for 30 min and subsequently removing the aneurysm clips for 60 min for reperfusion. Mg (600 mg/kg) and dexamethasone (0.25 mg/kg) were administered 20 min before the I/R insult. The lipid peroxidation in the brain tissue was determined by the concentration of thiobarbituric acid reactive substances (TBARS). The mitochondrial score was calculated after an evaluation with electron microscopy. RESULTS: Both the electron microscope and TBARS data showed a significant difference between the control and I/R groups. The Mg and dexamethasone treatment groups exhibited significantly lower TBARS values compared to the IR group. Similarly, the mitochondrial scores in the Mg and dexamethasone treatment groups were significantly lower than those in the I/R group. CONCLUSION: Result showed that magnesium sulfate and dexamethasone prevent lipid peroxidation and reduce mitochondrial injury thus suggests neuroprotective effects in fetal rat brain in intrauterine ischemia-reperfusion (I/R) injury.

a Topical term or geographic name as entry element Near East University Article

a Topical term or geographic name as entry element Yakın Doğu Üniversitesi Makale

a Topical term or geographic name as entry element Neurology

a Topical term or geographic name as entry element Dexamethasone;

a Topical term or geographic name as entry element Fetal brain;

a Topical term or geographic name as entry element Injury;

a Topical term or geographic name as entry element Intrauterine

a Topical term or geographic name as entry element Ischemia

a Topical term or geographic name as entry element Lipid peroxidation

a Topical term or geographic name as entry element Spınal-Cord-Injury

g Relationship information Sep 2013, Vol.23, Issue:5, p.666-671

t Title Turkısh Neurosurgery

x International Standard Serial Number 10195149

u Uniform Resource Identifier http://library.neu.edu.tr:2048/login?url=http://dx.doi.org/10.5137/1019-5149.JTN.8541-13.1