a Record control number 000311513800090

a ISSN 1357-0560

a Original cataloging agency NEU GrandLibrary

a Language code of text/sound track or separate title eng

a Classification number QZ200

b Item number .P74 2012

a Personal name Disel, Umut.

h Medium Electronic Document

a Title Prevalence of thyroid dysfunction in untreated cancer patients: a cross-sectional study.

c Statement of responsibility, etc Umut Disel, Ayberk Besen, Cemile Karadeniz, Huseyin Mertsoylu, Ahmet Sezer, Fatih Kose, Ahmet Taner Sumbul, Ozlem Gurkut, Sadık Muallaoğlu, Huseyin Abalı, Ozgur Ozyılkan.

b Name of publisher, distributor, etc Humana Press Inc.,

c Date of publication, distribution, etc 2012.

a Place of publication, distribution, etc Totowa :

a Summary, etc The relationship between thyroid disease and cancer (and cancer therapies) has been under investigation for years. Factors that increase the risk for thyroid disease include iodine deficiency, autoimmune disorders, old age, and pregnancy. The screening policy for thyroid disease in the healthy population is not precisely defined, and the frequency of thyroid dysfunction in untreated cancer patients has not been investigated in any great detail. This study was designed to compare the prevalence of thyroid dysfunction in 457 untreated cancer patients at the time of initial diagnosis to that of 373 age- and sex-matched subjects who were healthy and cancer-free (control group). Thyroid dysfunction was found in 29.5 % (135/457) of the cancer patients, while only 15.4 % (56/373) of the control group had thyroid dysfunction (p = 0.0001). The most prevalent abnormality was euthyroid sick syndrome (14.0 %, 64/457). Overt and subclinical hyperthyroidism and overt hypothyroidism were observed more frequently in cancer patients than the control group, and these differences were all statistically significant. Thyroid dysfunction was more frequent in patients with poor performance scores and those over the age of 50 years. These data indicate that alterations in thyroid hormone metabolism are twice as common in patients with untreated cancer than in control subjects. Those alterations may lead to delayed diagnosis, suboptimal treatment, and a poorer prognosis. In all, this study suggests that screening with thyroid function tests is strongly recommended in all newly diagnosed cancer patients.

a Topical term or geographic name as entry element Oncology

a Topical term or geographic name as entry element Near East University Article

a Topical term or geographic name as entry element Yakın Doğu Üniversitesi Makale

a Topical term or geographic name as entry element Cancer

a Topical term or geographic name as entry element Euthyroid sick syndrome

a Main entry heading Medical Oncology

g Relationship information DEC 2012, Vol 29 Issue 5, p3608-3613

x International Standard Serial Number 13570560

u Uniform Resource Identifier http://library.neu.edu.tr:2048/login?url=http://dx.doi.org/10.1007/s12032-012-0254-4